GERANYLGERANYL DIPHOSPHATE SYNTHASE INHIBITOR AND PROTEASOME INHIBITOR COMBINATION THERAPY IN MULTIPLE MYELOMA

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma

Abstract Background Multiple myeloma (MM) la rams crop top remains an incurable malignancy, despite the advent of therapies such as proteosome inhibitors (PIs) that disrupt protein homeostasis and induce ER stress.We have pursued inhibition of geranylgeranyl diphosphate synthase (GGDPS) as a novel mechanism by which to target protein homeostasis in

read more

Development of Cynicism in Medical Students: Exploring the Role of Signature Character Strengths and Well-Being

Reports of medical students experiencing burnout-related symptoms (e.g., cynicism) have increased in recent years.Little is known about the developmental process of this phenomenon and its relations with signature character strengths and well-being.The aim of this longitudinal analysis miracle academy clothing was to explore changes in the level of

read more



Power Flow Model for Medium-voltage Distribution Systems Considering Measurement and Structure Characteristics

Medium-voltage distribution systems (MVDSs) mainly consist of a feeder head, lines, distribution transformers, and the equivalent load or power supply interfaced with the distribution transformers.The information of such load or power supply can be measured via the three-wattmeter method (THM) and the two-wattmeter method (TWM).The measurements can

read more